Rationale and Objectives
This study aimed to assess the effect of matrix size on the spatial resolution and image quality of ultra-high-resolution computed tomography (U-HRCT).
Materials and Methods
Slit phantoms and 11 cadaveric lungs were scanned on U-HRCT. Slit phantom scans were reconstructed using a 20-mm field of view (FOV) with 1024 matrix size and a 320-mm FOV with 512, 1024, and 2048 matrix sizes. Cadaveric lung scans were reconstructed using 512, 1024, and 2048 matrix sizes. Three observers subjectively scored the images on a three-point scale (1 = worst, 3 = best), in terms of overall image quality, noise, streak artifact, vessel, bronchi, and image findings. The median score of the three observers was evaluated by Wilcoxon signed-rank test with Bonferroni correction. Noise was measured quantitatively and evaluated with the Tukey test. A P value of <.05 was considered significant.
Results
The maximum spatial resolution was 0.14 mm; among the 320-mm FOV images, the 2048 matrix had the highest resolution and was significantly better than the 1024 matrix in terms of overall quality, solid nodule, ground-glass opacity, emphysema, intralobular reticulation, honeycombing, and clarity of vessels ( P < .05). Both the 2048 and 1024 matrices performed significantly better than the 512 matrix ( P < .001), except for noise and streak artifact. The visual and quantitative noise decreased significantly in the order of 512, 1024, and 2048 ( P < .001).
Conclusion
In U-HRCT scans, a large matrix size maintained the spatial resolution and improved the image quality and assessment of lung diseases, despite an increase in image noise, when compared to a 512 matrix size.
Introduction
Advances in computed tomography (CT) have revolutionized diagnostic imaging. Various techniques, such as high-resolution CT, which was introduced in the 1980s, contributed to improvements in the spatial resolution of CT imaging . Recently, ultra-high-resolution CT (U-HRCT), which has smaller detector element and x-ray tube focus size than those of conventional CT, has become commercially available. Kakinuma et al. reported that a prototype U-HRCT provided better image quality of lung nodules than conventional CT . They also reported that the spatial resolution of the U-HRCT was 0.12 mm, whereas that of conventional CT ranged from 0.23 mm to 0.35 mm .
As for matrix size, 512 × 512 has been used in conventional CT, but larger matrix sizes, such as 1024 × 1024 and 2048 × 2048, are available with U-HRCT. When the reconstruction of the field of view (FOV) is set to 320 mm to cover the entire lung, the theoretical size of 1 pixel in an image matrix is 0.625 mm for 512 × 512; 0.313 mm for 1024 × 1024; and 0.156 mm for 2048 × 2048 ( Fig 1 ). Table 1 shows the theoretical size of 1 pixel according to matrix size and FOV reconstruction. We hypothesized that the size of 1 pixel in a smaller matrix image is much larger than the maximum spatial resolution of an U-HRCT scanner and insufficient to demonstrate the high spatial resolution of U-HRCT; on the other hand, a large matrix size may maintain the spatial resolution and improve the image quality of lung CT.
TABLE 1
The Theoretical Sizes of 1 Pixel According to Matrix Size and Reconstruction FOV
Reconstruction FOV 400 mm 320 mm 300 mm 200 mm 100 mm 75 mm Matrix size 512 × 512 0.781 0.625 0.586 0.391 0.195 0.146 1024 × 1024 0.391 0.313 0.293 0.195 0.098 0.073 2048 × 2048 0.195 0.156 0.146 0.098 0.049 0.036
FOV, field of view.
The unit of the theoretical sizes of 1 pixel is mm.
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Materials and Methods
U-HRCT Scanner
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Slit Phantom Evaluation
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Cadaveric Lung and Image Acquisition
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Subjective Image Analysis
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Objective Noise Analysis
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Statistical Analysis
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Results
Slit Phantom Evaluation
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Subjective Image Analysis of Cadaveric Lungs
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TABLE 2
Comparison of the Subjective Analysis Scores Among the Matrix Sizes
N Score (Mean ± SD)P Value 2048 1024 512 2048 vs 1024 2048 vs 512 1024 vs 512 Overall image quality 33 2.8 ± 0.4 2.0 ± 0.0 1.0 ± 0.0 <.001 \* <.001 \* <.001 \* Noise 33 1.0 ± 0.0 2.0 ± 0.0 3.0 ± 0.0 <.001 \* <.001 \* <.001 \* Streak artifact 33 2.0 ± 0.2 2.0 ± 0.2 2.0 ± 0.2 1 1 1 Clarity of small vessel 29 2.2 ± 0.4 2.0 ± 0.0 1.0 ± 0.0 .014 \* <.001 \* <.001 \* Clarity of small bronchi 29 2.1 ± 0.4 2.0 ± 0.0 1.0 ± 0.0 .046 <.001 \* <.001 \* Solid nodule 26 2.4 ± 0.5 2.0 ± 0.0 1.0 ± 0.0 .002 \* <.001 \* <.001 \* Faint nodule 11 2.4 ± 0.5 2.0 ± 0.0 1.0 ± 0.0 .046 .002 \* .001 \* Ground-glass opacity 25 2.3 ± 0.5 2.0 ± 0.0 1.0 ± 0.0 .008 \* .002 \* .001 \* Consolidation 11 2.2 ± 0.4 2.0 ± 0.0 1.0 ± 0.0 .157 .002 \* .001 \* Emphysema 12 2.6 ± 0.5 2.0 ± 0.0 1.0 ± 0.0 .008 \* .002 \* .001 \* Interlobular septal thickening 15 2.3 ± 0.5 1.9 ± 0.3 1.1 ± 0.2 .059 .001 \* <.001 \* Bronchovascular bundle thickening 12 2.0 ± 0.0 2.0 ± 0.0 1.0 ± 0.0 1 .001 \* .001 \* Intralobular reticulation 12 2.5 ± 0.5 2.0 ± 0.0 1.0 ± 0.0 .014 \* .002 \* .001 \* Bronchiectasis 9 2.0 ± 0.0 1.9 ± 0.3 1.0 ± 0.0 .317 .003 \* .005 \* Honeycombing 11 2.9 ± 0.3 2.0 ± 0.0 1.0 ± 0.0 .002 \* .001 \* .001 \*
CT, computed tomography; N, the number of the evaluated areas for each CT finding; SD, standard deviation.
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Objective Image Analysis
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Discussion
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Acknowledgments
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