Home The Effect of Susceptibility of Gadolinium Contrast Media on Diffusion-weighted Imaging and the Apparent Diffusion Coefficient
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The Effect of Susceptibility of Gadolinium Contrast Media on Diffusion-weighted Imaging and the Apparent Diffusion Coefficient

Rationale and Objectives

The development of parallel magnetic resonance imaging has resulted in the frequent use of diffusion-weighted imaging (DWI) in clinical medicine, which usually involves the use of contrast medium. However, gadolinium (Gd) contrast medium may have some effect on DWI and the apparent diffusion coefficient (ADC). The present study was performed to determine whether the magnetic susceptibility of contrast medium alters the DWI signal and the value of ADC in some imaging techniques.

Materials and Methods

Nonfat suppression DWI, short-time inversion recovery (STIR) combination, and chemical shift selective (CHESS) combination DWI were performed to examine 10 phantoms with gadolinium-meglumine gadopentetate (Gd-DTPA) dissolved at concentrations from 0.0005 to 0.1 mmol in physiologic saline as a contrast medium. The average pixel value and ADC of each method were determined.

Results

ADC showed no differences between before and after treatment with contrast medium for all imaging techniques with Gd considered distributed over the whole tumor. The signal intensity did not change on nonfat suppression or CHESS combination DWI, but deteriorated on STIR.

Conclusions

ADC was not influenced by the magnetic susceptibility of contrast medium. In addition, it was suggested that the ability of tumor detection may be reduced if STIR is used as fat suppression.

Diffusion-weighted imaging (DWI) has contributed to diagnosis as a new complement to magnetic resonance imaging. In particular, it has become the most important imaging technique in the diagnosis of acute stroke. With the recent development of parallel magnetic resonance imaging, DWI has often been used in clinical medicine to both search for tumors and as a discrimination diagnosis ( ).

However, the application of DWI in routine clinical examinations has not been established; therefore, DWI is often performed after use of contrast medium. There is concern regarding whether gadolinium (Gd) contrast medium influences the DWI signal and the value of the apparent diffusion coefficient (ADC).

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Materials and methods

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Figure 1, T1-weighted image and diffusion-weighted imaging of the nine phantoms that dissolved in physiologic saline from 0.0005 to 0.1 mmol in gadolinium-meglumine gadopentetate into a water tank.

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Results

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Figure 2, Quantity of gadolinium distribution before and after contrast medium for 20 meningiomas and 20 metastases to the brain. The quantity of gadolinium-meglumine gadopentetate (Gd-DTPA) distribution to a tumor by the contrast media dosage was estimated to be 0.001–0.005 mmol.

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Figure 3, The pixel value of 10 phantoms that dissolved in physiologic saline from 0.0005 to 0.1 mmol in gadolinium-meglumine gadopentetate (Gd-DTPA) were performed on diffusion-weighted imaging (DWI) nonfat suppression, short-time inversion recovery (STIR) combination DWI, and chemical shift selective (CHESS) combination DWI in b = 1000 × 10 −3 sec/mm 2 in a motion-probing gradient. Both nonfat suppression DWI and CHESS combination DWI showed similar signal intensity for gadolinium density. Signal value did not show a change to gadolinium density of 0.005 mmol, but showed a tendency to fall when density increased to more than 0.005 mmol.

Figure 4, A value of apparent diffusion coefficient (ADC) that calculated the motion-probing gradient from b = 0, 500, 1000 × 10 −3 sec/mm 2 in three imaging techniques of diffusion-weighted imaging (DWI) that nonfat suppression DWI, short-time inversion recovery (STIR) DWI, and chemical shift selective (CHESS) DWI using 10 phantoms that dissolved in a physiology solution of salt to 0.0005–0.1 mmol. Gd-DPTA, gadolinium-meglumine gadopenetate.

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Discussion

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Figure 5, Images using CHESS diffusion-weighted imaging before and after contrasting of meningiomas on the brain. Signal intensity shows that there were no changes before and after administration of contrast medium.

Figure 6, Images using STIR diffusion-weighted imaging before (STIR-Pre) and after use of contrast medium (STIR-CE)on a brain tumor. Signal intensity after contrast medium use decreased significantly compared to before administration of the contrast medium.

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Conclusions

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