Rationale and Objectives Hyperpolarized xenon-129 magnetic resonance (MR) provides sensitive tools that may detect early stages of lung disease in smokers before it has progressed to chronic obstr...

Introduction Spatial heterogeneity of lung aeration and strain (change volume/resting volume) occurs at microscopic levels and contributes to lung injury. Yet, it is mostly assessed with histogram...

Rationale and Objectives Chronic obstructive pulmonary disease is a heterogeneous disease characterized by small airway abnormality and emphysema. We hypothesized that a voxel-wise computed tomogr...

Rationale and Objectives To assess the repeatability of global and regional lung ventilation quantification in both healthy subjects and patients with chronic obstructive pulmonary disease (COPD) ...

Rationale and Objectives Chronic obstructive pulmonary disease (COPD) is highly heterogeneous and not well understood. Hyperpolarized xenon-129 (Xe129) magnetic resonance imaging (MRI) provides a ...

Rationale and Objectives In this study, we compared a newly developed multibreath simultaneous alveolar oxygen tension and apparent diffusion coefficient ( P A O 2 -ADC) imaging sequence to a sin...

Conventional pulmonary function tests appear normal in early cystic fibrosis (CF) lung disease. Therefore, new diagnostic approaches are required that can detect CF lung disease in children and mon...

A variety of imaging techniques have been utilized to study and further understand the pulmonary system over the past few decades. Researchers have refined and optimized techniques across a range o...

Objective To review the recent advances in available technologies for imaging COPD and present the novel optical coherence tomography (OCT) airway imaging technology. Materials and Methods This ...

Rationale and Objectives We propose an automated segmentation pipeline based on deep learning for proton lung MRI segmentation and ventilation-based quantification which improves on our previously...