Rationale and Objectives Photodynamic therapy (PDT) is a promising strategy for treating cancer. PDT involves three components: a photosensitizer (PS) drug, a specific wavelength of drug-activatin...

Rationale and Objectives Cancer cells generate more lactate than normal cells under both aerobic and hypoxic conditions—exhibiting the so-called Warburg effect. However, the relationship between t...

The papers published in this special issue of Academic Radiology were contributed following the International Symposium on Metabolic Imaging and Spectroscopy, organized at the University of Pennsyl...

The inclusion of anatomical prior information in reconstruction algorithms can improve the quality of reconstructed images in near-infrared diffuse optical tomography (DOT). Prior literature on pos...

Electron paramagnetic resonance (EPR) spectroscopy has been well established as a viable technique for measurement of free radicals and oxygen in biological systems, from in vitro cellular systems ...

Britton Chance, MD, PhD, D.Sc. was born in Wilkes-Barre, PA on July 24, 1913 and died on November 16, 2010. During his teenage, his family moved to Haverford, PA where he developed a passion for sa...

Rationale and objectives This study measures hemodynamic properties such as blood flow and hemoglobin concentration and oxygenation in the healthy human breast under a wide range of compressive lo...

The demand for functional imaging in clinical medicine is comprehensive. Although the gold standard for the functional imaging of human bones in clinical settings is still radionuclide-based imagin...

Rationale and Objectives Near-infrared spectroscopy (NIRS) of breast can provide functional information on the vascular and structural compartments of tissues in regions identified during simultan...

This is a first edition text based partly on Karim Valji’s excellent Vascular and Interventional Radiology , last published in 2006. The new title brings greatly expanded sections on bread-and-butt...