Rationale and Objectives Consider a study evaluating the prognostic value of prostate-specific antigen (PSA), in the presence of Gleason score, in differentiating between early and advanced prosta...

Rationale and Objectives Biomarkers are of ever-increasing importance to clinical practice and epidemiologic research. Multiple biomarkers are often measured per patient. Measurement of true bioma...

Rationale and Objectives Receiver operating characteristic (ROC) curves are ubiquitous in the analysis of imaging metrics as markers of both diagnosis and prognosis. While empirical estimation of ...

Rationale and Objectives To evaluate variability in the clinical assessment of breast images, we evaluated scoring behavior of radiologists in a retrospective reader study combining x-ray mammogra...

Rationale and Objectives Before using a new diagnostic imaging device regularly in a clinic, it should be studied using patients and radiologists. Often such studies report diagnostic performance ...

Rationale and Objectives Studies evaluating a new diagnostic imaging test may select control subjects without disease who are similar to case subjects with disease in regard to factors potentially...

Rationale and Objectives The goal of this study was to determine the accuracy and precision of using scores from a receiver operating characteristic rating scale to estimate sensitivity and specif...

Rationale and Objectives Grant funding institutions often require organizations to share their collected data as widely as possible while safeguarding the privacy of individuals. Summaries based o...

Rationale and Objectives The estimation of the area under the receiver operating characteristic (ROC) curve (AUC) often relies on the assumption that the truly positive population tends to have hi...

In the receiver operating characteristic paradigm the observer assigns a single rating to each image and the location of the perceived abnormality, if any, is ignored. In the free-response receiver...